Research Publications

We apply the highest scientific rigor to our work and share learnings to advance science that can benefit society. As a result, our research is frequently published in peer-reviewed journals. Review a selection of our most recent publications.

1. Building a translational cancer dependency map for The Cancer Genome Atlas
   Nature Cancer | 10.1038/s43018-024-00789-y
   AbbVie authors: Xu Shi, Christos Gekas, Daniel Verduzco, Sakina M Petiwala, Cynthia Leslie Jeffries, Charles Lu, Erin R Murphy, Tifani Won Suh Anton, Andy Hoang Vo, Zhiguang Xiao, Padmini Narayanan, Bee-Chun Sun, Aloma L. D'Souza, James Matthew Barnes, Somdutta Roy, Cyril Y. Ramathal, Zoltan Dezso
2. Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex
   Nature Communications Chemistry | 10.1038/s42004-024-01263-7
   AbbVie authors: Kelly Klinge, Christina Baumgertner, Keith Hamel, Jain Rinku, Kenton Longenecker, Charles Hutchins, Wei Qiu, Qi Sun, Vincent Stoll, Chaohong Sun, Michael Kort
3. Incorporating Synthetic Accessibility in Drug Design: Predicting Reaction Yields of Suzuki Cross-Couplings by Leveraging AbbVie’s 15-Year Parallel Library Data Set
   Journal of the American Chemical Society | 10.1021/jacs.4c00098
   AbbVie authors: Alex Joseph Rago *, Pritha Verma, Majdi Hassan, Gashaw Goshu, Amanda Worthy Dombrowski, Abhishek Pandey, Ying Wang
4. Janus Kinase Inhibitor Therapy and Risk of Age-Related Macular Degeneration in Autoimmune Diseases
   JAMA Ophthalmology | 10.1001/jamaophthalmol.2024.2376
   AbbVie authors: Joelle Hallak, Ali Abbasi, Changgeng Zhao, Yonghua Jing, Naijun Chen, Soumya Sahu, Ali Alobaidi, Ricardo López, Keith Allen Luhrs, Jeffrey F Waring, Anneke I Den Hollander, Nizar Smaoui
5. High-Throughput SFC-MS/MS Method to Measure EPSA and Predict Human Permeability
   Journal of Medicinal Chemistry | 10.1021/acs.jmedchem.4c00571
   AbbVie authors: Yueting Wang, Edward Francis Price, Mei Feng, Jason Hulen, Stella Z Doktor, David Stresser, Estelle Marie Maes, Qin Ji, Gary James Jenkins
6. Mining Medicinally Relevant Bioreduction Substrates Inspired by Ligand-Based Drug Design
   Journal of Medicinal Chemistry | 10.1021/acs.jmedchem.4c01129
   AbbVie Authors: Alex Joseph Rago *, Ioanna Zoi, Jackson Andrew Gartman, Kelly McDaniel, Navendu Jana, Dachun Liu, Wenju Bai
7. Coproporphyrin-I as a Selective OATP1B Biomarker Can Be Used to Delineate the Mechanisms of Complex Drug–Drug Interactions: Cedirogant Case Study
   Clinical Pharmacology and Therapeutics | 10.1002/cpt.3399
   AbbVie authors: Ryota Kikuchi, Yuli Qian, Mohamed Badawi, John Paul Savaryn, Shashikanth Gannu, Ann Katherine Eldred, Shuai Hao, Ahmed Salem, Wei Liu, Cheri Enders Klein, Mohamed-Eslam F. Mohamed
8. Parameter optimization for stable clustering using FlowSOM: a case study from CyTOF
   Frontiers in Immunology | 10.3389/fimmu.2024.1414400
   AbbVie authors: Weiyang Tao, Anirban Sinha, Khadir Raddassi, Aridaman Pandit
9. Unraveling the complexity of amorphous solid as direct ingredient for conventional oral solid dosage form: The story of Elagolix Sodium
   International Journal of Pharmaceutics | 10.1016/j.ijpharm.2024.124656
   AbbVie authors: Raimundo Ho, Richard S. Hong, Joseph Kalkowski, Kevin C Spence, Albert W Kruger, Jayanthy Jayanth, Nandkishor K Nere, Samrat Mukherjee, Ahmad Y Sheikh, Shailendra V Bordawekar
10. Inhibition of MALT1 and BCL2 Induces Synergistic Antitumor Activity in Models of B-Cell Lymphoma
    Molecular Cancer Therapeutics | 10.1158/1535-7163.MCT-23-0518
    AbbVie authors: Joshua P. Plotnik, Adam E. Richardson, Velitchka Dimitrova Bontcheva, Colleen Kate Dowell, Christine Will, Paul M Jung, Haizhong Zhu, Sarathy Karunan Partha, Sanjay C Panchal, Raghuveer Singh Mali, Fred Kohlhapp, Ryan Adam McClure, Cyril Y. Ramathal, Mariam D George, Manisha Jhala, Nathaniel L Elsen, Wei Qiu, Russell A Judge, Chin Pan, Anthony Mastracchio, Jonathan A Meulbroek, William N Pappano
11. Conquering the beyond Rule of Five Space with an Optimized High-Throughput Caco-2 Assay to Close Gaps in Absorption Prediction
    Pharmaceutics | 10.3390/pharmaceutics16070846
    AbbVie authors: Patricia Muschong, Khader Awwad, Edward Francis Price, Mario Mezler, Manuel Weinheimer
12. Proof of Concept of an All-in-One System for Measuring Hepatic Influx, Egress, and Metabolic Clearance Based on the Extended Clearance Concept
    Drug Metabolism and Disposition | 10.1124/dmd.124.001768
    AbbVie authors: Julia Annette Schulz Pauly *, Elizabeth Sande, Mei Feng, Yue-Ting Wang, David Stresser, John C Kalvass
13. Scale-up and clinical bioavailability assessment of a 45% drug loaded amorphous nanoparticle formulation of a BCS IV compound for oral delivery
    Journal of Pharmaceutical Science | 10.1016/j.xphs.2024.10.014
    AbbVie Authors: Miki Yu *, Deliang Zhou, Hardeep Singh Oberoi, Ahmed Salem, Laura Ann McKee, Jason R Arnholt, Hitesh S. Purohit, Devalina Law
14. The Current State of Biotransformation Science – Industry Survey of In Vitro and In Vivo Practices, Clinical Translation, and Future Trends
    Pharmaceutical Research | 10.1007/s11095-024-03787-y
    AbbVie authors: John Paul Savaryn, Elyse Freiberger, Gary James Jenkins
15. Quantitative Measurement of Rate of Targeted Protein Degradation
    ACS Chemical Biology | 10.1021/acschembio.4c00262
    AbbVie authors: Thomas Lawrence Lynch *, Violeta L. Marin, Ryan Adam McClure, Colin James Phipps, Judith A. Ronau, Milad Rouhimoghadam, Soumya Kandi, Malerie Wolke, Andrea Shergalis, Gregory Keith Potts, Omprakash Nacham, Stephan J Kakavas, Gekleng Chhor, Gary James Jenkins, Kevin R Woller, Scott E Warder, Anil Vasudevan, Justin M Reitsma
16. Collaborative robotics to enable ultra-high-throughput IR-MALDESI
    SLAS Technology | 10.1016/j.slast.2024.100163
    AbbVie authors: John Francis Shanley, Fan Pu, Jon D. Williams, Nathaniel L Elsen, Sujatha M Gopalakrishnan, Jeffrey Y Pan, Andrew Radosevich
17. Regenerative Skincare Technologies Derived From Human Fibroblasts: Growth Factors and Exosomes for Transformative Outcomes
    Dermatologic Surgery | 10.1097/DSS.0000000000004436
    AbbVie authors: Tsing Cheng, Elizabeth T Makino, Kuniko Kadoya, Prithwiraj Maitra
18. How predictive are isolated perfused liver data of in vivo hepatic clearance? A meta-analysis of isolated perfused rat liver data
    XENOBIOTICA | 10.1080/00498254.2024.2404170
    AbbVie authors: Julia Annette Schulz Pauly * John C Kalvass
19. Protein language models enable prediction of polyreactivity of monospecific, bispecific, and heavy-chain-only antibodies
    Antibody Therapeutics | 10.1093/abt/tbae012
    AbbVie authors: Xin Yu, Kostika Vangjeli, Anusha Prakash, Meha Chhaya, Samantha J. Stanley, Noah Cohen, Lili Huang
20. ABBV-319: a CD19-targeting glucocorticoid receptor modulator antibody-drug conjugate therapy for B-cell malignancies
    Blood | 10.1182/blood.2024023849
    AbbVie authors: Chewei Anderson Chang, Ethan Emberley, Aloma L. D’Souza, Weilong Zhao, Cormac Cosgrove, Karen Parrish, Diya Mitra, Elmer Payson, Anatol Oleksijew, Paul Ellis, Luis Rodriguez, Ryan Duggan, Cara Hrusch, Loren Lasko, Wissam Assaily, Pingping Zheng, Wei Liu, Axel Hernandez Jr, Kimberley McCarthy, Zhaomei Zhang, Geunbae Rha, Zhensheng Cao, Yingchun Li, Olivia Perng, Jos Campbell, Gloria Zhang, Tyler Curran, Milan Bruncko, Christopher C. Marvin, Adrian Hobson, Michael McPherson, Tamar Uziel, Marybeth A. Pysz, Xi Zhao, Alex Bankovich, Joel Hayflick, Michael McDevitt, Kevin J. Freise, Susan Morgan-Lappe, James W. Purcell
21. BCL-XL-targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors
    Science Advances | 10.1126/sciadv.ado7120
    AbbVie authors: Andrew S Judd, Bhupinder Bawa, Wayne R Buck, Zhi-Fu Tao, Yingchun Li, Michael J Mitten, Milan Bruncko, Nathaniel Catron, George A Doherty, Kenneth R Durbin, Brian Patrick Enright, Robin R Frey, Deanna L Haasch, Sandra T Haman, Anthony R Haight, Tracy Henriques, James H Holms, Kam Izeradjene, Russell A Judge, Gary James Jenkins, Aaron R Kunzer, Joel D Leverson, Ruth L Martin, Diya Mitra, Scott W Mittelstadt, Lorne Andrew Nelson, Paul M Nimmer, Joann Paulette Palma, Richard Peterson, Darren C. Phillips, Sherry L Ralston, Saul H Rosenberg, Xiaoqiang Shen, Xiaohong Song, Kedar R Vaidya, Xilu Wang, Jin Wang, Yu Xiao, Haichao Zhang, Xinxin Zhang, Eric A Blomme, Erwin R Boghaert, John C Kalvass, Andrew C Phillips, Andrew J Souers