AbbVie scientists combine deep biologic knowledge with cutting-edge
research technology to advance cancer care.
Regulated Cell Death - Apoptosis
Apoptosis is a form of regulated cell death, a natural process that eliminates damaged, unneeded or dangerous cells from the body.1 Through our deep knowledge of apoptosis and the role impaired apoptosis can play in the proliferation of cancer cells, we are advancing novel cancer research.
Immuno-oncology therapies aim to use the body’s own immune system to help fight cancer.2 Regular function of natural immune effector mechanisms for tumor detection and elimination may help prevent the growth and spread of tumors.
Interfering with the communication signals of malignant B cells is a potential strategy for treating some types of cancer.3 AbbVie is investigating key enzymes in the B cell receptor signaling complex that play an important role in the survival and expansion of malignant B cells.
Novel Tumor Targeting
Antigens are markers on cells that can be used to specifically target
cells that express the marker, including cancer cells, with
therapeutic agents. The ideal antigen is present on cancer cells but
not on normal cells. At AbbVie, we are leveraging our expertise across
multiple technology platforms to identify novel antigens and research
therapeutic approaches needed to target them.
What Do Tumors and Snowflakes Have in Common?
Through the use of new technologies, scientists are finding that like snowflakes, no two tumors are alike.
On-and-Off Switches for More Precise Medicines Against Cancer
Protein engineering is allowing researchers to program antibodies so they turn on and off in certain conditions to more precisely target tumors.
 Cory S, Huang DCS, Adams JM. The Bcl-2 family: roles in cell
survival and oncogenesis. Oncogene. 2003;22:8590-8607.
 Cancercare.org. Understanding the Role of Immuno-Oncology in Treating Cancer- Immuno-Oncology. Retrieved from: https://www.cancercare.org/publications/285-understanding_the_role_of_immuno-oncology_in_treating_cancer. Accessed January 2019.
 Burger, JA, Ghia P, et al. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood. 2009. 114:3367-3375
 National Cancer Institute (2018). NCI Dictionary of Cancer Terms: Antibody. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/antibody.
 Jarvis, LM. Targeted Protein Degraders Are Redefining How Small Molecules Look and Act. Chemical & Engineering News. https://cen.acs.org/articles/96/i8/targeted-protein-degraders-are-redefining-how-small-molecules-look-and-act.html. Accessed March 2019.
 Peters, C. & Brown, S. Antibody–drug conjugates as novel anti-cancer chemotherapeutics. Biosci Rep. 2015. 35:1-20.
 Dana Farber Cancer Institute. (2019). CAR T-Cell Therapy. [online] Available at: https://www.dana-farber.org/cellular-therapies-program/car-t-cell-therapy/ [Accessed 10 May 2019].