Research and discovery efforts battling COVID-19 and beyond

AbbVie is participating in the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) partnership led by the National Institutes of Health and the Foundation for the NIH (FNIH). The partnership brings together more than a dozen leading biopharmaceutical companies, the U.S. Centers for Disease Control and Prevention (CDC), the U.S. Food and Drug Administration (FDA), and the European Medicines Agency (EMA) to develop an international strategy for a coordinated research response to the COVID-19 pandemic. AbbVie assets are being studied as part of the ACTIV-5 Big Effect Trial and ACTIV-1 Immune Modulators trial. Learn more.

AbbVie is proud to be part of the COVID R&D Alliance, joining forces with others in the industry to help in the fight against COVID-19. Together we are working to identify, study, and accelerate the most promising therapeutic drug candidates, including the I-SPY clinical trial, to evaluate the efficacy of AbbVie’s cenicriviroc, a chemokine dual-receptor antagonist, in hospitalized COVID-19 patients who require high-flow oxygen. Learn more.

AbbVie is working with Harbour BioMed, Utrecht University, and Erasmus Medical Center to develop a novel antibody therapeutics to prevent and treat COVID-19. The focus of the collaboration is on advancing the fully human, neutralizing antibody 47D11, which targets the conserved domain of the spike protein of SARS-CoV-2, the virus that causes COVID-19. Learn more.

AbbVie has initiated a Phase 2 study of ibrutinib in patients with COVID-19 infection. The goal of this study is to determine whether ibrutinib can improve patient outcomes by diminishing the immune response known as the cytokine storm that contributes to the morbidity and mortality in COVID-19.

Along with industry partners, AbbVie has joined the Innovative Medicines Initiative’s Corona Accelerated R&D in Europe (CARE) consortium to support research and discovery of targeted medicines against COVID-19. Through our internal research and collaborations with external institutions and academia, we are focused on developing broadly neutralizing anti-COVID-19 antibodies and small molecule antivirals, which we will bring into clinical trials as quickly as possible. Learn more.

AbbVie and Harvard University are launching a $30 million research alliance to study and develop novel therapies against emergent viral infections. The specific focus of the collaboration will be on infections caused by coronaviruses and by viruses that lead to hemorrhagic fever. Together, AbbVie and Harvard Medical School aim to rapidly integrate fundamental biology into the preclinical and clinical development of new therapies for viral diseases that address a variety of therapeutic modalities. Learn more.