Research Publications

The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics by Karran et al. Nature Reviews Drug Discovery 2022

Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition by Judge et al. Nature Communications 2022 

Synovial Inflammatory Pathways Characterize Anti-TNF-Responsive Rheumatoid Arthritis Patients by Wang et al. Arthritis & Rheumatology 2022

Pathophysiologic and Pharmacologic Considerations to Improve the Design and Application of Antibody-Drug Conjugates by Boghaert et al. Cancer Research 2022

A data-driven and topological mapping approach for the a priori prediction of stable molecular crystalline hydrates by Hong et a. PNAS 2022

High-Throughput Intact Protein Analysis for Drug Discovery Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry by Pu et al. Analytical Chemistry 2022

Water structure in glycerol: Spectroscopic and computer simulation investigation of hydrogen bonding and water clustering by Wu et al. Journal of Molecular Liquids 2022

Antiviral Drug Discovery for the Treatment of COVID-19 Infections by Ng et al. Viruses 2022

Evaluation of Quantitative Platforms for Single Target Mass Spectrometry Imaging by Bowman et al. Pharmaceuticals 2022

Botulinum Neurotoxin Type A Directly Affects Sebocytes and Modulates Oleic Acid-Induced Lipogenesis by Brami-Cherrier et al. Toxins 2022

Risk of Severe COVID-19 Outcomes Among Patients with Immune-Mediated Inflammatory Diseases or Malignancies: A Retrospective Analysis of Real-World Data in the United States by Yue et al. Advances in Therapy 2022

Detecting crystallinity in amorphous solid dispersions using dissolution testing: Considerations on properties of drug substance, drug product, and selection of dissolution media by Purohit et al. Journal of Pharmaceutical Sciences 2022

Design of a Re-Dispersible High Drug Load Amorphous Formulation by Oberoi et al. Journal of Pharmaceutical Science

Systems genomics in age-related macular degeneration by Den Hollander et al. Experimental Eye Research

Interdisciplinary model-informed drug development for extending duration of elagolix treatment in patients with uterine fibroids by Beck et al. British Journal of Clinical Pharmacology

BTK-1: A Novel Positron Emission Tomography Tracer for Imaging Bruton’s Tyrosine Kinase by Skaddan et al. Molecular Imaging and Biology

In vitro inflammatory and immune response to uncrosslinked hyaluronic

Venetoclax increases intratumoral effector t cells and antitumor efficacy in combination with immune checkpoint blockade by Kohlhapp et al. Cancer Discovery, 2021 (IF 29.497)

Harnessing cerebrospinal fluid circulation for drug delivery to brain tissues by Naseri Kouzehgarani et al. Advanced Drug Delivery Reviews, 2021 (IF 13.3)

Foslevodopa/Foscarbidopa: A New Subcutaneous Treatment for Parkinson's Disease by Rosenbraugh et al. Annals of Neurology, 2021 (IF 9.037)

High-Throughput Label-Free Biochemical Assays Using Infrared Matrix-Assisted Desorption Electrospray Ionization Mass Spectrometry by Pu et al. Analytical Chemistry, 2021 (IF 6.785) 

Optimized Culture Conditions for Improved Growth and Functional Differentiation of Mouse and Human Colon Organoids by Wilson et al. Frontiers in Immunology, 2021 (IF 5.085)

Collecting antibodies and large molecule biomarkers in mouse interstitial brain fluid: a comparison of microdialysis and cerebral open flow microperfusion by Le Prieult et al. MAbs, 2021 (IF 4.634)

Validation of a quantitative systems pharmacology model of calcium homeostasis using elagolix Phase 3 clinical trial data in women with endometriosis by Stodtman et al. Clinical Translational Science, 2021 (IF 3.373)

Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer by Faivre et al.  Nature, 2020 (IF 42.779)

A balance score between immune stimulatory and suppressive microenvironments identifies mediators of tumour immunity and predicts pan-cancer survival by Turan et al. British Journal of Cancer, 2020 (IF 5.791)

Epitope and Fc-mediated cross-linking, but not high affinity, are critical for antitumor activity of CD137 agonist antibody with reduced liver toxicity by Ho et al. Molecular Cancer Therapeutics, 2020 (IF 5.615)

Coproporphyrin I Can Serve as an Endogenous Biomarker for OATP1B1 Inhibition: Assessment Using a Glecaprevir/Pibrentasvir Clinical Study by Kalluri et al. Clinical Translational Science, 2020 (IF 3.373) 

Machine learning prediction of oncology drug targets based on protein and network properties by Dezso et al BMC Bioinformatics, 2020 (IF 3.242)

Evaluation of Tissue Stem Cell–Derived Human Intestinal Organoids, a Physiologically Relevant Model to Evaluate Cytochrome P450 Induction in Gut by Stresser et al. Drug Metabolism and Disposition, 2020 (IF 3.231)

Use of Zebrafish in Drug Discovery Toxicology by Cassar et al. Chemical Research in Toxicology, 2019 (IF 3.184)