Research Publications

We apply the highest scientific rigor to our work and share learnings to advance science that can benefit society. As a result, our research is frequently published in peer-reviewed journals. Review a selection of our most recent publications.

1. Ritonavir Form III: A New Polymorph After 24 Years
   Journal of Pharmaceutical Sciences | DOI: 10.1016/j.xphs.2022.09.026
   AbbVie authors: Xin Yao, Rodger F. Henry, Geoff G.Z. Zhang
   
   
2. Dissolution Mechanisms of Amorphous Solid Dispersions: Role of Drug Load and Molecular Interactions
   Molecular Pharmaceutics | DOI: 10.1021/acs.molpharmaceut.2c00892
   AbbVie authors: Anura S. Indulkar, Hitesh S. Purohit, Yi Gao, Geoff G.Z. Zhang
   
   
3. Pregnancy Outcomes in Patients Exposed to OnabotulinumtoxinA Treatment: A Cumulative 29-Year Safety Update
   Neurology | DOI: 10.1212/WNL.0000000000207375
   AbbVie Authors: Mitchell F. Brin, Russell S. Kirby, Anne Slavotinek, Aubrey Manack Adams, Lori Parker, Ahunna Ukah, Lavinia Radulian, Monica R.P. Elmore, Larisa Yedigarova, Irina Yushmanova
   
   
4. iBRIDGE: A Data Integration Method to Identify Inflamed Tumors from Single-Cell RNAseq Data and Differentiate Cell Type-Specific Markers of Immune-Cell Infiltration
   Cancer Immunology Research | DOI: 10.1158/2326-6066.CIR-22-0283
   AbbVie Authors: Tolga Turan, Sarah Kongpachith, Kyle Halliwill, Robert T. McLaughlin, Mikhail Binnewies, Xi Zhao, Rebecca Mathew, Shiming Ye, Howard J. Jacob, Josue Samayoa
   
   
5. CRISPR Screen Reveals BRD2/4 Molecular Glue-like Degrader via Recruitment of DCAF16
   ACS Chemical Biology | DOI: 10.1021/acschembio.2c00747
   AbbVie authors: Andrea G. Shergalis, Violeta L. Marin, David Y. Rhee, Sameera Senaweera, Rebecca L. McCloud, Judith A. Ronau, Charles W. Hutchins, Shaun McLoughlin, Kevin R. Woller, Scott E. Warder, Anil Vasudevan, Justin M. Reitsma
   
   
6. Plasma protein-mediated uptake and contradictions to the free drug hypothesis: a critical review
   Drug Metabolism Reviews | DOI: 10.1080/03602532.2023.2195133
   AbbVie authors: Julia Annette Schulz, David M. Stresser, John Cory Kalvass
   
   
7. In-vitro modeling of intravenous drug precipitation by the optical spatial precipitation analyzer (OSPREY)
   International Journal of Pharmaceutics | DOI: 10.1016/j.ijpharm.2023.122842
   AbbVie authors: Andrew J. Radosevich, Ruth L. Martin, Wayne R. Buck, Lauren Hicks, Amanda Wilsey, Jeffrey Y. Pan
   
   
8. Applying Quantitative Approaches in the Use of RWE in Clinical Development and Life-Cycle Management
   Statistics in Biopharmaceutical Research | DOI: 10.1080/19466315.2021.1927827
   AbbVie authors: Weili He, Yixin Fang, Hongwei Wang
   
   
9. Accelerated Storage for Shelf-Life Prediction of Lyophiles: Temperature Dependence of Degradation of Amorphous Small Molecular Weight Drugs and Proteins
   Journal of Pharmaceutical Science | DOI: 10.1016/j.xphs.2023.02.008
   AbbVie authors: Evgenyi Shalaev, Ehab M. Moussa
   
   
10. Assumptions Underlying Hepatic Clearance Models: Recognizing the Influence of Saturable Protein Binding on Driving Force Concentration and Discrimination Between Models of Hepatic Clearance
    Drug Metabolism and Disposition | DOI: 10.1124/dmd.123.001326
    AbbVie authors: Julia A. Schulz Pauly, Jin Wang, Colin J. Phipps, John Cory Kalvass
    
    
11. Integrity and efficiency: AbbVie's journey of building an integrated nonregulated bioanalytical laboratory
    Bioanalysis | DOI: 10.4155/bio-2023-0012
    AbbVie authors: Yue-Ting Wang, Estelle M. Maes, Lance Heinle, Kenneth Ruterbories, Stella Doktor, Mary Larsen, Amanda Olson, Andrew Lee, Cecilia Van Handel, Qin C. Ji, Kelly Desino, Gary J. Jenkins
    
    
12. Bioanalytical strategy for the characterization and bioanalysis of biologics: a global, nonregulated bioanalytical lab perspective
    Bioanalysis | DOI: 10.4155/bio-2022-0215
    AbbVie authors: Hetal Sarvaiya, Shuai Niu, Daniel T. Ladror, Yuting Wang, Dolonchampa Maji, Malerie Wolke, Paramasivam Natarajan, Gary J. Jenkins
    
    
13. The Clinical Response of Upadacitinib and Risankizumab Is Associated With Reduced Inflammatory Bowel Disease Anti-TNF-α Inadequate Response Mechanisms
    Inflammatory Bowel Diseases | DOI: 10.1093/ibd/izac246
    AbbVie authors: Jing Wang, Michael Macoritto, Heath Guay, Justin W. Davis, Marc C. Levesque, Xiaohong Cao
    
    
14. Preclinical species gene expression database: Development and meta-analysis
    Frontiers in Genetics | DOI: 10.3389/fgene.2022.1078050