B-cell signaling

Interfering with the communication signals of malignant B cells is a potential strategy for treating some types of cancer.

Why it matters...

  • AbbVie is a leader in the research of Bruton’s tyrosine kinase (BTK), a key enzyme in the B cell receptor signaling complex that plays an important role in the survival and expansion of malignant B cells.1
  • AbbVie is researching other B cell signaling pathways.

Learn more about B-cell signaling:

BTK protein: The good, the bad and
the ugly

BTK helps immune function, but its malfunction may lead to cancer and autoimmune diseases. Scientists are investigating new approaches in both areas.

Learn more

[1] Pal Singh et al. Molecular Cancer (2018) 17:57 https://doi.org/10.1186/s12943-018-0779-z. Accessed January 2019.