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THE FUTURE OF ABBVIE IMMUNOLOGY:

Building on a Foundation of Strength

The needs of people with immune-mediated disease drive our work to create innovative, effective solutions.

150+

active immunology clinical trials

6

new molecular compounds in Phase I, II or III clinical trials in immunology

9

immune-mediated inflammatory conditions under investigation

50+

countries with active clinical trials in immunology

Our Vision for the Future

For more than 20 years, we have focused on forging new paths for the treatment of immune-mediated diseases. Years of clinical studies have revealed that, despite significant advances, patients’ needs persist. As we look forward, our commitment to making a remarkable impact in patients’ lives remains and we must grow to find solutions where they’re most needed. We have a bold vision for the future: one in which we have an answer for even more patients. Guided by real patient experiences, we’re investigating three key focus areas within immunology.

Leading the Way

We are relentlessly developing a robust pipeline of potential new therapies to address different targets, and we are using a variety of technology platforms—from biologics to small molecules to bispecifics—to find and deliver solutions for patients’ biggest challenges.

We are even evaluating a new platform called DVD-Ig, a technology with the potential to combine two different antibodies targeting two different disease pathways into one medicine.

Current and Prospective Targets

Several targets play an important role in the advancement of our robust immunology pipeline.

TNF- α

A cytokine that contributes to the induction and maintenance of the inflammatory immune response

IL-1

Two related cytokine proteins, IL-1 α/β, play a role in acute and chronic inflammation

IL-6

A cytokine that plays a key role in immune-mediated inflammatory disease

IL-13

A cytokine that induces tissue inflammation, epithelial hypertrophy and may play a role in asthma

IL-17

A cytokine produced by T cells that mediate inflammatory responses when produced in excess

IL-23

A cytokine that shares a subunit with IL-12 and works to mediate inflammatory responses

RORγT

A protein that binds to DNA and regulates the production of other key pro-inflammatory proteins

JAK1

An enzyme that signals and initiates the response of other cytokines involved in the body’s immune response

CD40

A protein receptor expressed by B cells, macrophages and dendritic cells that is involved in mediating inflammatory responses

BTK

An enzyme that activates the production and growth of B cells, which produce antibodies that help the body protect itself

Want to learn more about our targeted technology platforms and therapeutic targets?
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Explore Our Portfolio

Risankizumab

Risankizumab is an investigational treatment that selectively blocks interleukin-23 (IL-23), a key signaling agent that has been linked to a number of chronic immune-mediated diseases. Risankizumab is being evaluated in multiple inflammatory diseases, including psoriasis, Crohn’s disease and psoriatic arthritis. Efficacy and safety have not been established.

Upadacitinib

Upadacitinib is an investigational oral agent engineered to selectively inhibit JAK1, which plays an important role in the pathophysiology of rheumatoid arthritis and other immune-mediated inflammatory disorders. Upadacitinib is being studied in rheumatoid arthritis, psoriatic arthritis, Crohn’s disease, ulcerative colitis and atopic dermatitis. Efficacy and safety have not been established.

HUMIRA® (adalimumab)

HUMIRA is an anti-TNF monoclonal antibody.
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Rheumatology

We’re focused on changing the lives of patients with rheumatoid arthritis, psoriatic arthritis, uveitis, juvenile idiopathic arthritis, and ankylosing spondylitis.

Dermatology

Patients with plaque psoriasis, psoriatic arthritis, atopic dermatitis and hidradenitis suppurativa drive our dermatology work.

Gastroenterology

We’re reshaping the patient journey for people with Crohn’s disease and ulcerative colitis.

Behind the Science

Leader Spotlight

Immunology at AbbVie: In the Lab with Lisa Olson
AbbVie’s Lisa Olson, PhD, vice president of immunology research, shares how AbbVie is approaching innovation to lead the way in the treatment of immune-mediated diseases with next generation breakthrough therapies.
Read Story

Lisa Olsen

Join Our Team

Our team of immunology experts is focused on improving the standard of care for this generation and the next. We’re committed, curious, and passionate; and we’re hiring.
Search all immunology jobs

Join The Team

AbbVie Immunology In the News

AbbVie's Upadacitinib Granted Breakthrough Therapy Designation from the U.S. Food and Drug Administration for Atopic Dermatitis
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AbbVie's Upadacitinib Shows Positive Results as Monotherapy in Phase 3 Rheumatoid Arthritis Study, Meeting All Primary and Key Secondary Endpoints
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Risankizumab Meets All Co-Primary and Ranked Secondary Endpoints, Achieving Significantly Greater Efficacy Versus Standard Biologic Therapies in Three Pivotal Phase 3 Psoriasis Studies
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AbbVie to Showcase Robust Immunology Portfolio with New and Late-Breaking Data at the 2017 ACR/ARHP Annual Meeting
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AbbVie's Upadacitinib (ABT-494) Meets All Primary and Ranked Secondary Endpoints in Second Phase 3 Study in Rheumatoid Arthritis
Read More

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