Neuroscience

We are dedicated to delivering science that brings us closer to making a significant impact for people living with neurological and psychiatric disorders. 

Breaking barriers with cutting-edge research

In the field of neuroscience, there are many tough-to-treat disorders with high unmet need. Our researchers and scientists are relentless in their pursuit of raising the standards of care through innovative approaches to help patients.

But the brain is complex, and new challenges require new ways of thinking across all stages of drug discovery and development. That’s why we are continuously exploring innovative approaches to address some of the most prevalent and serious brain disorders, from Parkinson’s and Alzheimer’s to migraine and schizophrenia.


What we're up against

Brain disorders encompass a broad set of neurological and psychiatric conditions with potentially devastating effects. They can alter the way people think, feel and move, causing identities to slip away and connections – past, present and future – to be lost.


Research interests

Despite these challenges, progress in the field of neuroscience has advanced in recent years and AbbVie is leading the way. We are harnessing new tools, innovations in research methods and an enhanced understanding of biology to drive key scientific advancements and optimism for the future of neuroscience.

To deliver the next wave of medicines in neuroscience, we’re committed to being at the forefront of science and technology. Our current research focus areas include:

  • Investigating disease mechanisms supported by human genetics, disease pathology, human induced pluripotent stem cell (iPSC) cell types and animal models with construct validity.
  • For proteinopathy diseases, focusing on the biology of pathological proteins, mitochondrial/lysosomal dysfunction, proteostasis, neuroinflammation, neuroprotection, and neurorestoration, with the aim of preventing the spread and accelerating the clearance of toxic intracellular protein aggregates.
  • Exploring novel approaches in addition to small molecules and biologics that offer a wide range of drug targets aimed at improving blood-brain barrier crossing and long-lasting effects – enhancing convenience and efficacy for prescribers and patients.
  • Optimizing clinical trial design by leveraging novel technologies including machine learning and AI to accelerate the development of new therapies.
  • Searching for novel biomarkers to measure effects of investigational drugs during clinical trials.
  • Using state-of-the-art technologies in imaging, proteomics, single particle detection and single-cell RNAseq to advance science faster.

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Neuroscience focus areas

Our neuroscience pipeline consists of innovative, investigational medicines, including symptomatic treatments, disease-modifying approaches, therapeutic toxins and other cutting-edge strategies to address brain disorders. Backed by more than three decades of research, we are focused on four key areas.


Focus areas

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